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Multicenter Study
. 2007 Aug;138(4):513-6.
doi: 10.1111/j.1365-2141.2007.06682.x. Epub 2007 Jun 29.

A Clinical Score Predicting a Brief and Uneventful Course of Newly Diagnosed Idiopathic Thrombocytopenic Purpura in Children

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Multicenter Study

A Clinical Score Predicting a Brief and Uneventful Course of Newly Diagnosed Idiopathic Thrombocytopenic Purpura in Children

Pernille Wendtland Edslev et al. Br J Haematol. .

Abstract

The Nordic idiopathic thrombocytopenic purpura study data showed that morbidity occurred mainly in children with thrombocytopenia lasting >3 months, whereas, the risk period with platelet counts <20 x 10(9)/l was short and the number of bleeding events low in children with shorter disease duration. These brief, uneventful courses were predicted by developing a scoring system based on six clinical features: abrupt onset (weight 5), age <10 years (3), preceding infection (2), platelet count <5 x 10(9)/l, wet purpura (1) and male gender (1). The score was derived and validated in two different cohorts of children. High scores (10-14) clearly identified low-risk patients. The score provides valid prognostic information and may be useful in clinical decision-making.

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