Comparison of the effectiveness of commonly used clinic-based treatments for external genital warts

Int J STD AIDS. 2007 Jun;18(6):365-8. doi: 10.1258/095646207781024711.


We describe a prospective study designed to assess the effectiveness of the commonly used clinic-based treatments for genital warts individually and in combination. Patients presenting with new or recurrent genital warts were randomly allocated to one of five treatments on a weekly basis. The clinical endpoint was wart clearance or eight treatments, whichever occurred sooner. If there was not a good response by the eighth treatment, an alternate modality was offered. Four hundred and nine individuals were enrolled in the study. Almost no patients withdrew in any group due to adverse effects. Three-quarters of patients treated with podophyllin 25% and cryotherapy concurrently required only two treatments to clear their warts. All had clearance in less than eight treatments. Single therapy with either trichloracetic acid or podophyllin 25% resulted in longer time to wart clearance, and more persistent warts.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Ambulatory Care Facilities
  • Caustics / therapeutic use
  • Combined Modality Therapy
  • Condylomata Acuminata / drug therapy
  • Condylomata Acuminata / therapy*
  • Cryotherapy / methods*
  • Female
  • Humans
  • Keratolytic Agents / therapeutic use
  • Male
  • Podophyllin / therapeutic use*
  • Prospective Studies
  • Trichloroacetic Acid / therapeutic use*


  • Caustics
  • Keratolytic Agents
  • Trichloroacetic Acid
  • Podophyllin