The role of VLA4 polymorphisms in multiple sclerosis: an association study

J Neuroimmunol. 2007 Sep;189(1-2):125-8. doi: 10.1016/j.jneuroim.2007.06.015. Epub 2007 Jul 3.


Lymphocyte and monocyte brain infiltration determines inflammation in multiple sclerosis. The trafficking of these cells into the CNS results from the VLA-4 binding with its ligand on brain endothelial cells. MS patients treated with an antibody against the alpha-4 subunit, which inhibits this interaction, prevents brain lesion development. We investigated the association between VLA-4 gene polymorphisms and MS in a study on 275 patients and 255 controls. No differences were detected, thus suggesting that these polymorphisms are not a significant genetic risk factor for susceptibility to MS in Italy.

MeSH terms

  • Adult
  • Alleles
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Humans
  • Integrin alpha4beta1 / genetics*
  • Italy / epidemiology
  • Male
  • Middle Aged
  • Multiple Sclerosis / genetics*
  • Polymorphism, Genetic / genetics*


  • Integrin alpha4beta1