Background: Herpes simplex virus (HSV) is the leading cause of infectious corneal blindness in the developed world. Eighty percent of the general population develop asymptomatic viral latency in the trigeminal ganglion following orofacial inoculation, but only 0.2% of all such orofacial inoculations are followed by recurrent corneal reactivation. Recurrences still threaten graft survival following penetrating keratoplasty, so that advance identification of patients at increased risk would be helpful in aftercare following penetrating keratoplasty. The HLA B27 phenotype is associated with increased susceptibility to genital HSV. However, no such association has been reported for herpetic eye disease.
Methods: The HLA phenotypes of 129 patients who underwent penetrating keratoplasties for herpetic corneal scars were available for retrospective analysis. Four of these patients were positive for HLA-B27. The 125 HLA-B27-negative patients served as controls. The mean follow-up was 2.2 years. We compared the frequencies of herpetic recurrence and graft failure in the two groups using the Kaplan-Meier method and applied log-rank statistics.
Results: After the average period of follow-up, 75% (three patients) of the HLA B27-positive patients experienced either graft failure or at least one reversible recurrence of the herpetic eye disease, as against only 25% of controls. This difference was highly statistically significant (p<0.01).
Conclusion: This retrospective analysis suggests that the HLA B27 phenotype promotes recurrence of herpetic eye disease following penetrating keratoplasty. HLA B27-positive patients should be closely monitored, and the indications for prophylactic antiviral therapy should be viewed liberally in this group.