Regulation of membrane fusion in synaptic excitation-secretion coupling: speed and accuracy matter

Neuron. 2007 Jul 5;55(1):11-24. doi: 10.1016/j.neuron.2007.06.013.


Unlike most other secretory processes, neurotransmitter release at chemical synapses is extremely fast, tightly regulated, spatially restricted, and dynamically adjustable at the same time. In this review, we focus on recent discoveries of molecular and cell biological processes that determine how fusion competence of vesicles is achieved and controlled in order to suit the specific requirements of synaptic transmitter release with respect to speed and spatial selectivity.

Publication types

  • Review

MeSH terms

  • Animals
  • Exocytosis / physiology
  • Humans
  • Membrane Fusion / physiology*
  • Neurotransmitter Agents / metabolism*
  • Neurotransmitter Agents / physiology*
  • SNARE Proteins / physiology
  • Signal Transduction / physiology
  • Synapses / metabolism*
  • Synapses / physiology*
  • Synaptic Vesicles / physiology


  • Neurotransmitter Agents
  • SNARE Proteins