POEMS syndrome: relapse after successful autologous peripheral blood stem cell transplantation

Neuromuscul Disord. 2007 Dec;17(11-12):980-2. doi: 10.1016/j.nmd.2007.05.004. Epub 2007 Jul 3.

Abstract

We report a patient with POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) treated with high dose chemotherapy and auto-Peripheral Blood Stem Cell Transplantation (auto-PBSCT) who had a very good response with complete clinical remission. Seven years later, she relapsed and a new sclerotic bone lesion was found. To our knowledge, this is the first POEMS syndrome relapse after successful auto-PBSCT.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers / blood
  • Cervical Vertebrae / diagnostic imaging
  • Cervical Vertebrae / pathology*
  • Drug Therapy
  • Female
  • Humans
  • Osteosclerosis / etiology*
  • Osteosclerosis / pathology*
  • Osteosclerosis / physiopathology
  • POEMS Syndrome / physiopathology
  • POEMS Syndrome / therapy*
  • Peripheral Blood Stem Cell Transplantation*
  • Radiosurgery
  • Recurrence
  • Tomography, X-Ray Computed
  • Treatment Failure
  • Vascular Endothelial Growth Factor A / blood

Substances

  • Biomarkers
  • Vascular Endothelial Growth Factor A