Treating prostate cancer: a rationale for targeting local oestrogens

Nat Rev Cancer. 2007 Aug;7(8):621-7. doi: 10.1038/nrc2174. Epub 2007 Jul 5.


Prostate cancer is the most commonly diagnosed cancer and the second most common cause of cancer-related death in men, and benign prostatic hyperplasia is the most common benign condition known to occur in ageing men. Oestrogen has been implicated in the development of prostate cancer, and offers a promising new avenue for treatment. Despite this, the role of oestrogens in the prostate is complex. This Perspective presents a rationale for a targeted approach for the treatment of prostate disease through the use of selective oestrogen-receptor modulators in conjunction with contemporary androgen-ablation therapy.

Publication types

  • Review

MeSH terms

  • Estrogen Receptor Modulators / therapeutic use*
  • Estrogens / metabolism*
  • Humans
  • Male
  • Prostatic Neoplasms / drug therapy*
  • Prostatic Neoplasms / metabolism


  • Estrogen Receptor Modulators
  • Estrogens