Hepatitis B immune globulin

Drugs Today (Barc). 2007 Jun;43(6):379-94. doi: 10.1358/dot.2007.43.6.1050792.


Hepatitis B immune globulin (HBIG) is a purified solution of human immunoglobulin that has high titers of antibody to hepatitis B surface antigen (anti-HBs). It is derived from plasma donated by individuals immune to hepatitis B viral infection. HBIG is widely administered to confer passive prophylactic immunity against the hepatitis B virus because of the ability of anti-HBs to neutralize hepatitis B virions. However, it is not indicated for the treatment of acute or chronic hepatitis B. The use of HBIG is recommended in the following clinical situations: i) Acute exposure to blood and secretions containing hepatitis B surface antigen (HBsAg); ii) sexual contact with HBsAg-positive persons; iii) household exposure to persons with acute hepatitis B; iv) perinatal exposure of infants born to HBsAg-positive mothers; v) liver transplantation.

Publication types

  • Review

MeSH terms

  • Drug Interactions
  • Female
  • Hepatitis B / immunology
  • Hepatitis B / prevention & control*
  • Hepatitis B / transmission
  • Hepatitis B Antibodies* / administration & dosage
  • Hepatitis B Antibodies* / adverse effects
  • Hepatitis B Antibodies* / immunology
  • Humans
  • Immunization, Passive
  • Immunoglobulins* / administration & dosage
  • Immunoglobulins* / adverse effects
  • Immunoglobulins* / immunology
  • Infectious Disease Transmission, Vertical / prevention & control
  • Liver Transplantation
  • Male
  • Pregnancy
  • Recurrence


  • Hepatitis B Antibodies
  • Immunoglobulins