Clinical efficacy of citalopram alone or augmented with bupropion in methadone-stabilized patients

Am J Addict. 2007 May-Jun;16(3):187-94. doi: 10.1080/10550490701375640.


Despite the success of opiate-agonist therapies such as methadone for the treatment of opiate addiction, treatment response is not complete. This study evaluates the efficacy of citalopram augmented with bupropion in the treatment of illicit opiate use in a methadone-stabilized population. We conducted a 12-week randomized, double-blind, outpatient clinical trial in which 60 subjects were randomized into one of three treatment groups: placebo, citalopram (40 mg/day) plus placebo, or citalopram (40 mg/day) plus bupropion (50 mg/day). The results indicate that neither citalopram nor citalopram augmented with bupropion were more effective than placebo in the treatment of opioid abuse.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Analgesics, Opioid / therapeutic use*
  • Anxiety Disorders / etiology
  • Bupropion / therapeutic use*
  • Citalopram / therapeutic use*
  • Cocaine-Related Disorders / drug therapy
  • Cocaine-Related Disorders / psychology
  • Cocaine-Related Disorders / urine
  • Depressive Disorder / etiology
  • Dopamine Uptake Inhibitors / therapeutic use*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Methadone / therapeutic use*
  • Middle Aged
  • Opioid-Related Disorders / drug therapy*
  • Opioid-Related Disorders / psychology
  • Opioid-Related Disorders / urine
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*


  • Analgesics, Opioid
  • Dopamine Uptake Inhibitors
  • Serotonin Uptake Inhibitors
  • Bupropion
  • Citalopram
  • Methadone