Gamma-glutamyltransferase, redox regulation and cancer drug resistance

Curr Opin Pharmacol. 2007 Aug;7(4):360-6. doi: 10.1016/j.coph.2007.04.004. Epub 2007 Jul 5.


Gamma-glutamyltransferase, a key enzyme of GSH metabolism, can modulate crucial redox-sensitive functions, such as antioxidant/antitoxic defences and cellular proliferative/apoptotic balance, with potential implications in tumour progression and drug resistance. Recent studies have elucidated the mechanisms of GGT involvement in various pathological processes suggesting its potential role as therapeutic target and diagnostic/prognostic marker.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Drug Delivery Systems
  • Drug Resistance, Neoplasm
  • Glutathione / metabolism
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / physiopathology
  • Oxidation-Reduction
  • Prognosis
  • gamma-Glutamyltransferase / metabolism*


  • Antineoplastic Agents
  • gamma-Glutamyltransferase
  • Glutathione