Nuclear Mechanics and Methods

Methods Cell Biol. 2007;83:269-94. doi: 10.1016/S0091-679X(07)83011-1.


The role of the nucleus in protecting and sequestering the genome is intrinsically mechanical, and disease-causing structural mutants in lamins and other components underscore this function. Various methods to measure nuclear mechanics, isolated or in situ, are outlined here in some detail.

MeSH terms

  • Biomechanical Phenomena / methods*
  • Cell Nucleus / chemistry*
  • Cell Nucleus / ultrastructure
  • Cytoskeleton / chemistry
  • Rheology / methods