Quality of life before and one year following stem cell transplantation using an individualized and a standardized instrument

Psychooncology. 2008 Apr;17(4):338-46. doi: 10.1002/pon.1240.


Objective: The aim was to prospectively measure quality of life in patients with malignant blood disorders following stem cell transplantation (SCT) using an individualized and a standardized measure.

Methods: Twenty-two consecutive patients were assessed before and one year following SCT, using a generic and disease-related version of the Schedule for the Evaluation of Individual Quality of Life-Direct Weighting (SEIQoL-DW) and the EORTC QLQ-C30. Results of the QLQ-C30 were compared with Swedish norm values.

Results: A majority of the patients reported concerns related to health before as well as one year after SCT, recorded by both instruments. Mean scores produced by the SEIQoL-DW, and four scales of the EORTC QLQ-C30, showed a change over time, indicating improved quality of life one year after SCT. In comparison with Swedish norm values for the EORTC QLQ-C30, SCT recipients reported a worse functioning.

Conclusions: In addition to well-known disease and treatment-related problems, areas not typically included in standardized instruments were nominated in the disease-related SEIQoL-DW. Such areas included positive aspects, e.g. a changed view of life and oneself. The results support the use of the generic and disease-related SEIQoL-DW to achieve a comprehensive picture of patient's clinical situation under treatment or when recovering from illness.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Psychological
  • Adult
  • Aged
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Hematopoietic Stem Cell Transplantation / psychology*
  • Hodgkin Disease / psychology
  • Hodgkin Disease / therapy*
  • Humans
  • Leukemia, Myeloid, Acute / psychology
  • Leukemia, Myeloid, Acute / therapy*
  • Lymphoma, Non-Hodgkin / psychology
  • Lymphoma, Non-Hodgkin / therapy*
  • Male
  • Middle Aged
  • Multiple Myeloma / psychology
  • Multiple Myeloma / therapy*
  • Personality Inventory / statistics & numerical data
  • Psychometrics
  • Quality of Life / psychology*
  • Reference Values
  • Remission Induction
  • Sick Role
  • Sickness Impact Profile


  • Antineoplastic Agents