Epithelioid hemangioendothelioma with multiple organ involvement

APMIS. 2007 Jul;115(7):881-8. doi: 10.1111/j.1600-0463.2007.apm_727.x.


Epithelioid hemangioendothelioma is a rare vascular neoplasm of uncertain malignant potential. Various reports document metastatic or concurrent epithelioid hemangioendothelioma in several sites, most commonly with combined lung and liver involvement. The concurrent involvement of multiple sites at presentation may cause diagnostic problems because epithelioid hemangioendothelioma can mimic other neoplastic processes. Although it is a chemo-resistant disease, chemotherapy is usually advised for patients with metastatic or concurrent involvement. Here we document the presentation, treatment, and outcome of two cases with concurrent involvement of the lung and liver.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Female
  • Hemangioendothelioma, Epithelioid / diagnostic imaging*
  • Hemangioendothelioma, Epithelioid / drug therapy
  • Hemangioendothelioma, Epithelioid / pathology
  • Humans
  • Liver Neoplasms / diagnostic imaging*
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / pathology
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Radiography
  • Treatment Outcome