Comparison of uptake between PureSorb-Q40 and regular hydrophobic coenzyme Q10 in rats and humans after single oral intake

J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):187-90. doi: 10.3177/jnsv.53.187.


Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant and essential component of the mitochondrial electron transfer system in the body, and is in wide use as a functional food material and cosmetic raw material. However, as CoQ10 is extremely lipid-soluble, absorption by the body is not easy. In general, people use soft-gel capsules in which CoQ10 is suspended in oil, and take these capsules with food. PureSorb-Q40 (P40) was developed to improve CoQ10 processability and absorption when taken without food, and the present study compared the effects of food on absorption between P40 and conventional lipid-soluble CoQ10 in rats and humans. The results of a rat study showed higher uptake when P40 was administered in the fasting state or with food compared to lipid-soluble CoQ10. The results of a human study showed that uptake was favorable when P40 was administered in the fasting state, and even when administered postprandially, a significant difference was noted in uptake rate up to 6 h after intake and uptake volume up to 8 h after intake when compared to lipid-soluble CoQ10. These results show that any CoQ10 product using P40 can be quickly and reliably absorbed by the body regardless of dosage form or intake time.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / metabolism
  • Antioxidants / pharmacokinetics*
  • Capsules
  • Chromatography, High Pressure Liquid / methods
  • Coenzymes / administration & dosage
  • Coenzymes / blood
  • Coenzymes / metabolism
  • Coenzymes / pharmacokinetics*
  • Cross-Over Studies
  • Food
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Male
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Reference Values
  • Tablets
  • Time Factors
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / blood
  • Ubiquinone / pharmacokinetics
  • Vitamins / administration & dosage
  • Vitamins / blood
  • Vitamins / pharmacokinetics*


  • Antioxidants
  • Capsules
  • Coenzymes
  • PureSorb-Q40
  • Tablets
  • Vitamins
  • Ubiquinone
  • coenzyme Q10