Actin in membrane trafficking

Curr Opin Cell Biol. 2007 Aug;19(4):453-8. doi: 10.1016/j.ceb.2007.04.017. Epub 2007 Jul 5.

Abstract

Actin cytoskeleton remodeling provides the forces required for a variety of cellular processes based on membrane dynamics, such as endocytosis, exocytosis, and vesicular trafficking at the Golgi. All these events are coordinated by networks of associated proteins, and some of them are functionally connected with cell migration. The site and the duration of actin polymerization, in connection with vesicle budding and fusion, are tightly controlled by both small GTPases and the large GTPase dynamin. Recent advances in the understanding of the mechanisms coupling actin dynamics with membrane trafficking at the cell surface have been brought by the combined studies of actin polymerizing factors and of the endocytic/exocytic machinery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / physiology*
  • Animals
  • Cell Membrane / physiology*
  • Endocytosis / physiology
  • Exocytosis / physiology
  • Humans
  • Models, Biological
  • Protein Transport
  • rab GTP-Binding Proteins / physiology

Substances

  • Actins
  • rab GTP-Binding Proteins