Antiarrhythmic induced electrical storm in Brugada syndrome: a case report

Ann Noninvasive Electrocardiol. 2007 Jul;12(3):274-8. doi: 10.1111/j.1542-474X.2007.00171.x.


Brugada syndrome (BS) may be "unmasked" by several pharmacological and/or physiological agents in an otherwise normal electrocardiogram. Once diagnosed the possibility of persistent ventricular tachycardia/fibrillation exists. Although this is treated with various antiarrhythmic agents, there remains a cohort of patients who fail to respond to conventional antiarrhythmic therapy therefore, amplifying the electrical storm. We report a case of a BS diagnosed via procainamide challenge, the resultant near fatal electrical storm aggravated by amiodarone and the eventual resolution with isoproterenol.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic beta-Agonists / therapeutic use*
  • Amiodarone / adverse effects*
  • Anti-Arrhythmia Agents
  • Brugada Syndrome / diagnosis
  • Brugada Syndrome / physiopathology*
  • Defibrillators, Implantable
  • Electrocardiography
  • Female
  • Humans
  • Isoproterenol / therapeutic use*
  • Middle Aged
  • Procainamide
  • Tachycardia, Ventricular / chemically induced*
  • Tachycardia, Ventricular / physiopathology
  • Tachycardia, Ventricular / prevention & control
  • Vasodilator Agents / adverse effects*
  • Ventricular Fibrillation / chemically induced*
  • Ventricular Fibrillation / physiopathology
  • Ventricular Fibrillation / prevention & control


  • Adrenergic beta-Agonists
  • Anti-Arrhythmia Agents
  • Vasodilator Agents
  • Procainamide
  • Isoproterenol
  • Amiodarone