VDAC closure increases calcium ion flux

Biochim Biophys Acta. 2007 Oct;1768(10):2510-5. doi: 10.1016/j.bbamem.2007.06.002. Epub 2007 Jun 12.


VDAC is the major permeability pathway in the mitochondrial outer membrane and can control the flow of metabolites and ions. Therefore Ca(2+) flux across the outer membrane occurs mainly through VDAC. Since both Ca(2+) fluxes and VDAC are involved in apoptosis, we examined whether Ca(2+) is required for channel formation by VDAC isolated from rat liver. The voltage gating of VDAC does not require Ca(2+) and it functions normally with or without Ca(2+). Additionally, VDAC generally shows a higher permeability to Ca(2+) in the closed states (states with lower permeability to metabolites) than that in the open state. Thus VDAC closure, which induces apoptosis, also favors Ca(2+) flux into mitochondria, which can also lead to permeability transition and cell death. These results are consistent with the view that VDAC closure is a pro-apoptotic signal.

MeSH terms

  • Animals
  • Apoptosis
  • Calcium / metabolism*
  • Chlorides / metabolism
  • Ion Channel Gating
  • Osmolar Concentration
  • Permeability
  • Rats
  • Voltage-Dependent Anion Channels / physiology*


  • Chlorides
  • Voltage-Dependent Anion Channels
  • Calcium