Long-term follow-up of very old heart failure patients enrolled in a trial of exercise training

Am J Geriatr Cardiol. 2007 Jul-Aug;16(4):243-8. doi: 10.1111/j.1076-7460.2007.06488.x.


Little is known about how physical and psychological status changes with time in older heart failure patients. The authors followed up a cohort of 82 patients (mean age, 80.5 years) enrolled in a randomized controlled trial of exercise training in heart failure. Six-minute walk test, accelerometry, functional status, quality of life, anxiety, and depression were measured at baseline, 3 months, 6 months, and a mean of 19 months post-enrollment. There were no significant differences between the exercise and control groups at long-term follow-up. Six-minute walk distance declined by only 0.2 m/month in those attending final follow-up (vs 4.6 m/month in nonattenders; P=.03). Similar results were seen for other outcomes. Only a small proportion of the variance in change of any of the outcomes was explained by differences in baseline variables.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Anxiety
  • Depression
  • Exercise Therapy*
  • Female
  • Health Status
  • Heart Failure / mortality
  • Heart Failure / psychology
  • Heart Failure / therapy*
  • Humans
  • Male
  • Prognosis
  • Prospective Studies
  • Quality of Life
  • Time Factors
  • Treatment Outcome*