Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives

Oya Bozdağ-Dündar; Ozen Ozgen; Arzu Menteşe; Nurten Altanlar; Onur Atli; Engin Kendi; Rahmiye Ertan

doi:10.1016/j.bmc.2007.06.049

Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives

Bioorg Med Chem. 2007 Sep 15;15(18):6012-7. doi: 10.1016/j.bmc.2007.06.049. Epub 2007 Jun 29.

Authors

Oya Bozdağ-Dündar¹, Ozen Ozgen, Arzu Menteşe, Nurten Altanlar, Onur Atli, Engin Kendi, Rahmiye Ertan

Affiliation

¹ Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Tandoğan, Ankara, Turkey. bozdag@pharmacy.ankara.edu.tr

PMID: 17618124
DOI: 10.1016/j.bmc.2007.06.049

Abstract

In this study, a series of thiazolyl thiazolidine-2,4-dione derivatives (Va-f and VIa-f) were synthesized and evaluated for their antibacterial and antifungal activities against Staphylococcus aureus (ATCC 25923), methicillin resistant S. aureus (MRSA ATCC 43300), methicillin resistant S. aureus (MRSA isolate), and Escherichia coli (ATCC 23556) and C. albicans (ATCC10145). All the compounds were found active against used microorganisms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
Candida albicans / drug effects
Candida albicans / growth & development
Escherichia coli / drug effects
Escherichia coli / growth & development
Methicillin / pharmacology
Methicillin Resistance
Microbial Sensitivity Tests
Models, Chemical
Molecular Structure
Staphylococcus aureus / drug effects
Staphylococcus aureus / growth & development
Thiazolidines / chemical synthesis*
Thiazolidines / chemistry
Thiazolidines / pharmacology

Substances

Anti-Bacterial Agents
Antifungal Agents
Thiazolidines
Methicillin