Oral lipid-based formulations

Adv Drug Deliv Rev. 2007 Jul 30;59(7):667-76. doi: 10.1016/j.addr.2007.05.006. Epub 2007 May 26.

Abstract

Poor drug solubility remains a significant and frequently encountered problem for pharmaceutical scientists. The ability of lipid-based formulations to facilitate gastrointestinal absorption of many poorly soluble drug candidates has been thoroughly documented in the published literature. However, a considerable gap exists between our knowledge of this technology and the know-how required for its application. This commentary provides a comprehensive summary of the development, characterization, and utilization of oral lipid-based formulations, from both physicochemical and biopharmaceutical perspectives. The characteristics of currently available lipid excipients are reviewed in context of their application to the basic lipid-based formulation modalities. The fundamental concepts of in vitro and in vivo evaluation of lipid-based formulations are summarized followed by a forward-looking summary of unrealized opportunities and potential limitations to more widespread use of this technology.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Chemical Phenomena
  • Chemistry, Pharmaceutical
  • Chemistry, Physical
  • Drug Delivery Systems*
  • Drug Stability
  • Excipients / chemistry
  • Lipids / chemistry*
  • Oils / chemistry
  • Pharmaceutical Preparations / administration & dosage
  • Pharmaceutical Preparations / chemistry*
  • Solubility
  • Solvents
  • Surface-Active Agents / chemistry

Substances

  • Excipients
  • Lipids
  • Oils
  • Pharmaceutical Preparations
  • Solvents
  • Surface-Active Agents