Evaluation of the EIE-IgM-Leptospirose assay for the serodiagnosis of leptospirosis

Acta Trop. 2007 Jun;102(3):206-11. doi: 10.1016/j.actatropica.2007.05.002. Epub 2007 May 22.


Access to low-cost, effective diagnosis for leptospirosis is urgently needed in developing countries. The EIE-IgM-Leptospirose, a kit produced for public health laboratories in Brazil, was shown to have a sensitivity of 76% (77 of 102 patients) and 100% (102 of 102 patients) during acute and convalescent-phase leptospirosis, respectively, and a specificity of 93-100% (total healthy and patient control subjects evaluated, 486). These findings indicate that the assay will be useful for diagnosis of this emerging infectious disease in Brazil and other developing countries.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brazil / epidemiology
  • Enzyme-Linked Immunosorbent Assay*
  • Humans
  • Immunoglobulin M / analysis*
  • Leptospirosis / diagnosis*
  • Leptospirosis / epidemiology
  • Leptospirosis / immunology*
  • Reagent Kits, Diagnostic*
  • Sensitivity and Specificity
  • Serologic Tests


  • Immunoglobulin M
  • Reagent Kits, Diagnostic