Acute exposure to low-level CW and GSM-modulated 900 MHz radiofrequency does not affect Ba 2+ currents through voltage-gated calcium channels in rat cortical neurons

Bioelectromagnetics. 2007 Dec;28(8):599-607. doi: 10.1002/bem.20345.


We have studied the non-thermal effects of radiofrequency (RF) electromagnetic fields (EMFs) on Ba(2+) currents (I Ba 2+) through voltage-gated calcium channels (VGCC), recorded in primary cultures of rat cortical neurons using the patch-clamp technique. To assess whether low-level acute RF field exposure could modify the amplitude and/or the voltage-dependence of I Ba 2+, Petri dishes containing cultured neurons were exposed for 1-3 periods of 90 s to 900 MHz RF-EMF continuous wave (CW) or amplitude-modulated according to global system mobile communication standard (GSM) during whole-cell recording. The specific absorption rates (SARs) were 2 W/kg for CW and 2 W/kg (time average value) for GSM-modulated signals, respectively. The results obtained indicate that single or multiple acute exposures to either CW or GSM-modulated 900 MHz RF-EMFs do not significantly alter the current amplitude or the current-voltage relationship of I Ba 2+, through VGCC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Barium / metabolism*
  • Calcium Channels / physiology*
  • Calcium Channels / radiation effects
  • Cell Phone*
  • Cells, Cultured
  • Cerebral Cortex / physiology*
  • Cerebral Cortex / radiation effects*
  • Dose-Response Relationship, Radiation
  • Ion Channel Gating / physiology
  • Ion Channel Gating / radiation effects
  • Microwaves
  • Neurons / physiology*
  • Neurons / radiation effects*
  • Radiation Dosage
  • Rats
  • Rats, Sprague-Dawley
  • Signal Processing, Computer-Assisted


  • Calcium Channels
  • Barium