A polyvinyl alcohol core coil containing basic fibroblast growth factor evaluated in rabbits with aneurysms induced by elastase

Neurosurgery. 2007 Jul;61(1):160-6; discussion 166. doi: 10.1227/01.neu.0000279737.07683.57.


Objective: The present study evaluates the effect of a novel coil with a polyvinyl alcohol (PVA) core that delivered basic fibroblast growth factor (bFGF) to aneurysms in rabbits induced by elastase.

Methods: PVA was processed to form small threads and inserted into the central core of a primary coil (PVA-core coil). After immersion in saline or bFGF (500 or 2000 mug/ml), PVA-core coils were implanted into elastase-induced aneurysms in rabbits in vivo. Follow-up angiography was performed 4 and 8 weeks after embolization, and the effects were histologically semiquantified according to a grading scale.

Results: Follow-up angiography showed that the coils did not compact or protrude and that clots did not form in any group. The score of gross neck healing was significantly higher in the 8-week 2000 bFGF group than in the 8-week PVA coil group (2.7 +/- 0.6 versus 0.0 +/- 0.0, P < 0.05). The dome healing score was significantly higher in the 4-week 2000 bFGF group than that of the 4-week PVA coil group (4.0 +/- 0.0 versus 2.7 +/- 0.6, P < 0.05). Cells positive for alpha-smooth muscle actin densely accumulated in the dome of the aneurysm embolized with PVA-core coils containing bFGF.

Conclusion: Implantation of the PVA-core coil containing bFGF accelerated tissue growth at the neck as well as in the dome of aneurysms induced by elastase in rabbits. These results suggested that PVA-core coils could prevent the recanalization of embolized aneurysms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Combined Modality Therapy
  • Drug Implants / administration & dosage*
  • Drug Implants / chemistry*
  • Embolization, Therapeutic / instrumentation*
  • Embolization, Therapeutic / methods*
  • Equipment Design
  • Equipment Failure Analysis
  • Fibroblast Growth Factor 2 / administration & dosage*
  • Fibroblast Growth Factor 2 / chemistry
  • Intracranial Aneurysm / chemically induced
  • Intracranial Aneurysm / therapy*
  • Pancreatic Elastase
  • Polyvinyl Alcohol / chemistry*
  • Rabbits
  • Treatment Outcome


  • Drug Implants
  • Fibroblast Growth Factor 2
  • Polyvinyl Alcohol
  • Pancreatic Elastase