X-ray sensitivity of fibroblast cell strains derived from atomic bomb survivors with and without breast cancer

J Radiat Res. 1991 Mar:32 Suppl:330-8. doi: 10.1269/jrr.32.supplement_330.


Fibroblasts were established in vitro from skin biopsies obtained from 55 women and 1 man with or without breast cancer and with or without exposure to radiations from the atomic bomb (A-bomb) explosion in Hiroshima. The radiosensitivity of these cells was evaluated by clonogenic assays after exposure to X-rays. Dose-response curves were fitted to a multitarget model, S/S0 = A[1-(1-e-D/D0)N]. There was no difference in the means or variances of radiosensitivity between exposed and nonexposed groups, or between groups with and without breast cancer.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Breast Neoplasms / etiology
  • Breast Neoplasms / pathology*
  • Cell Survival / radiation effects*
  • Female
  • Humans
  • In Vitro Techniques
  • Japan
  • Male
  • Neoplasms, Radiation-Induced / etiology
  • Neoplasms, Radiation-Induced / pathology*
  • Nuclear Warfare*
  • Radiation Tolerance
  • Survival