Replication in context: dynamic regulation of DNA replication patterns in metazoans

Nat Rev Genet. 2007 Aug;8(8):588-600. doi: 10.1038/nrg2143. Epub 2007 Jul 10.


Replication in eukaryotes initiates from discrete genomic regions according to a strict, often tissue-specific temporal programme. However, the locations of initiation events within initiation regions vary, show sequence disparity and are affected by interactions with distal elements. Increasing evidence suggests that specification of replication sites and the timing of replication are dynamic processes that are regulated by tissue-specific and developmental cues, and are responsive to epigenetic modifications. Dynamic specification of replication patterns might serve to prevent or resolve possible spatial and/or temporal conflicts between replication, transcription and chromatin assembly, and facilitate subtle or extensive changes of gene expression during differentiation and development.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Cell Differentiation
  • DNA Replication / genetics*
  • DNA Replication / physiology*
  • Embryonic Development
  • Genomic Instability
  • Humans
  • Models, Genetic
  • Multiprotein Complexes
  • Origin Recognition Complex / chemistry
  • Origin Recognition Complex / metabolism
  • Transcription, Genetic


  • Multiprotein Complexes
  • Origin Recognition Complex