Prevalence of BRCA1 expression in epithelial ovarian cancer: immunohistochemical study

J Med Assoc Thai. 2007 Jan;90(1):9-14.


The 99 formalin fxed paraffin-embedded ovarian tissue specimens of Epithelial Ovarian Cancer (EOC) patients treated at the Gynecologic Oncology Unit, King Chulalongkorn Memorial Hospital between January 1, 1996 and December 31, 1999, were immuno-stained with BRCA antibody using the immunohistochemical method. According to the criteria for BRCA1 immunohistochemical evaluation (neoplastic nuclear staining more than 10%), 12 (12.1%) of the 99 specimens showed positive BRCA1 expression. No associated statistical significance between clinicopathological variables and BRCA expression was detected. Survival analysis was performed in 87 patients who were followed-up for more than 6 months and recent status were available. During a median follow-up of 43 months, median survival time was 46 months (range 6-84 months). No association between BRCA1 expression and survival outcomes was found (Disease free survival and overall survival) in the presented patients.

MeSH terms

  • Disease-Free Survival
  • Female
  • Gene Expression
  • Genes, BRCA1
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / metabolism
  • Ovarian Neoplasms / mortality
  • Paraffin Embedding
  • Survival Analysis