The Role of XAF1 in Cancer

Curr Opin Investig Drugs. 2007 Jun;8(6):469-76.

Abstract

The inhibitors of apoptosis (IAP) proteins have emerged as important cancer targets. The cellular control of IAP expression is regulated by survival signaling pathways and by a variety of known intrinsic antagonists. Among these antagonists, the X-linked IAP-associated factor (XAF)1 is unique in its control of IAP function and in its ability to sensitize cancer cells to apoptosis. Studies have demonstrated that XAF1 is strongly pro-apoptotic, is inducible by IFN and is a tumor suppressor. Thus, this antagonist may have significant value in the treatment of cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis / drug effects
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Molecular Sequence Data
  • Neoplasm Proteins / drug effects
  • Neoplasm Proteins / genetics*
  • Neoplasms / genetics*

Substances

  • Intracellular Signaling Peptides and Proteins
  • Neoplasm Proteins
  • XAF1 protein, human