Age-related decline of sleep-dependent consolidation

Learn Mem. 2007 Jul 10;14(7):480-4. doi: 10.1101/lm.569407. Print 2007 Jul.


Sleep-dependent memory consolidation is observed following motor skill learning: Performance improvements are greater over a 12-h period containing sleep relative to an equivalent interval without sleep. Here we examined whether older adults exhibit sleep-dependent consolidation on a sequence learning task. Participants were trained on one of two sequence learning tasks. Performance was assessed after a 12-h break that included sleep and after a 12-h break that did not include sleep. Older and younger adults showed similar degrees of initial learning. However, performance of the older adults did not improve following sleep, providing evidence that sleep-dependent consolidation is diminished with age.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Circadian Rhythm
  • Female
  • Humans
  • Learning / physiology
  • Male
  • Memory / physiology*
  • Middle Aged
  • Reaction Time / physiology
  • Sleep / physiology*
  • Sleep Wake Disorders / physiopathology*