The intracellular region of Notch ligands: does the tail make the difference?

Biol Direct. 2007 Jul 10;2:19. doi: 10.1186/1745-6150-2-19.


The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals.