Fatal valproate overdose in a newborn baby

Hum Exp Toxicol. 2007 May;26(5):453-6. doi: 10.1177/0960327107076835.

Abstract

Valproate is a widely used drug in the treatment of epilepsy in children and adults. However, it is not safe for patients under two years of age, especially during the newborn period. This study presents a case of fatal valproate overdose in a 26-day-old female newborn, who is the youngest patient in the literature.

Publication types

  • Case Reports

MeSH terms

  • Anticonvulsants / poisoning*
  • Brain Edema / chemically induced*
  • Brain Edema / complications
  • Brain Edema / diagnostic imaging
  • Drug Overdose
  • Fatal Outcome
  • Female
  • Heart Arrest / etiology
  • Humans
  • Infant, Newborn
  • Tomography, X-Ray Computed
  • Valproic Acid / poisoning*

Substances

  • Anticonvulsants
  • Valproic Acid