A comparison of three organ dysfunction scores: MODS, SOFA and LOD for predicting ICU mortality in critically ill patients

J Med Assoc Thai. 2007 Jun;90(6):1074-81.


Objective: To compare the validity of the Multiple Organ Dysfunction Score (MODS), Sequential Organ Failure Assessment (SOFA), and Logistic Organ Dysfunction Score (LOD) for predicting ICU mortality of Thai critically ill patients.

Material and method: A retrospective study was made of prospective data collected between the 1st July 2004 and 31st March 2006 at Songklanagarind Hospital.

Results: One thousand seven hundred and eighty two patients were enrolled in the present study. Two hundred and ninety three (16.4%) deaths were recorded in the ICU. The areas under the Receiver Operating Curves (A UC) for the prediction of ICU mortality the results were 0.861 for MODS, 0.879 for SOFA and 0.880 for LOD. The AUC of SOFA and LOD showed a statistical significance higher than the MODS score (p = 0.014 and p = 0.042, respectively). Of all the models, the neurological failure score showed the best correlation with ICU mortality.

Conclusion: All three organ dysfunction scores satisfactorily predicted ICU mortality. The LOD and neurological failure had the best correlation with ICU outcome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Critical Illness*
  • Female
  • Hospitals, University
  • Humans
  • Intensive Care Units*
  • Male
  • Middle Aged
  • Multiple Organ Failure / classification
  • Multiple Organ Failure / diagnosis*
  • Multiple Organ Failure / mortality
  • Prognosis
  • Retrospective Studies
  • Severity of Illness Index*
  • Thailand / epidemiology
  • Time Factors