Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells

Cell Calcium. Oct-Nov 2007;42(4-5):373-8. doi: 10.1016/j.ceca.2007.05.012. Epub 2007 Jul 10.


One of the most crucial aspects of Ca(2+) signalling is the ability to generate highly localised transient elevations of the cytosolic Ca(2+) concentration at specific strategically important target sites. Inevitably this necessitates a relatively high Ca(2+) buffering power of the cytoplasm, which in turn makes movement of Ca(2+) from one part of a cell to another difficult. Nature has evolved an elegant solution to this problem by creating operational Ca(2+) tunnels through the endoplasmic reticulum. Very recently direct evidence that such tunnelling also occurs in neurons has been provided.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Signaling*
  • Cell Polarity*
  • Endoplasmic Reticulum / metabolism*
  • Neurons / metabolism


  • Calcium