Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome?

Diabetologia. 2007 Sep;50(9):1880-1888. doi: 10.1007/s00125-007-0758-1. Epub 2007 Jul 12.


Aims/hypothesis: The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor for cardiovascular disease and type 2 diabetes. The aim of the present study was to evaluate whether there are common genetic and environmental factors influencing this cluster in a general population of twin pairs.

Materials and methods: A multivariate genetic analysis was performed on nine endophenotypes associated with the metabolic syndrome from 625 adult twin pairs of the GEMINAKAR study of the Danish Twin Registry.

Results: All endophenotypes showed moderate to high heritability (0.31-0.69) and small common environmental variance (0.05-0.21). In general, genetic and phenotypic correlations between the endophenotypes were strong only within sets of physiologically similar endophenotypes, but weak to moderate for other pairs of endophenotypes. However, moderate correlations between insulin resistance indices and either obesity-related endophenotypes or triacylglycerol levels indicated that some common genetic backgrounds are shared between those components.

Conclusions/interpretation: We demonstrated that, in a general population, the endophenotypes associated with the metabolic syndrome apparently do not share a substantial common genetic or familial environmental background.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Adult
  • Aged
  • Blood Pressure
  • Body Mass Index
  • Environment
  • Female
  • Humans
  • Insulin Resistance / genetics
  • Insulin Resistance / physiology
  • Lipids / blood
  • Lipoproteins / blood
  • Male
  • Metabolic Syndrome / etiology
  • Metabolic Syndrome / genetics*
  • Middle Aged
  • Obesity / genetics
  • Obesity / physiopathology
  • Phenotype
  • Twins, Dizygotic
  • Twins, Monozygotic


  • Lipids
  • Lipoproteins