The Role of cyclooxygenase-2 in Breast Cancer: Review

Breast Cancer Res Treat. 2008 May;109(2):189-98. doi: 10.1007/s10549-007-9641-5. Epub 2007 Jul 12.

Abstract

There is a growing body of evidence that COX-2 expression s a fundamental step in breast cancer pathogenesis acting through prostaglandin-dependent and independent mechanisms. Epidemiological studies suggest that NSAIDs confer a moderate degree of benefit against breast cancer. However further work is required to establish how this enzyme system can be best manipulated for therapeutic benefit.

Publication types

  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / enzymology*
  • Breast Neoplasms / genetics
  • Cyclooxygenase 2 / genetics
  • Cyclooxygenase 2 / metabolism*
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans

Substances

  • Cyclooxygenase 2