The ins and outs of phosphate homeostasis

Kidney Int. 2007 Jul;72(2):140-2. doi: 10.1038/sj.ki.5002005.

Abstract

A complication of chronic renal failure is hyperphosphatemia. An apparently straightforward manipulation to treat this--restriction of dietary phosphate--has proven that phosphate homeostasis is more complicated than we currently understand. This Commentary describes recent findings on novel regulatory factors that contribute to phosphate homeostasis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Calcitriol
  • Fibroblast Growth Factor-23
  • Fibroblast Growth Factors
  • Homeostasis
  • Humans
  • Hypophosphatemia / drug therapy
  • Hypophosphatemia / etiology
  • Kidney Failure, Chronic / complications*
  • Kidney Failure, Chronic / drug therapy
  • Metabolic Networks and Pathways
  • Phosphates / physiology*
  • Phosphates / therapeutic use

Substances

  • Phosphates
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Calcitriol