Abstract
A complication of chronic renal failure is hyperphosphatemia. An apparently straightforward manipulation to treat this--restriction of dietary phosphate--has proven that phosphate homeostasis is more complicated than we currently understand. This Commentary describes recent findings on novel regulatory factors that contribute to phosphate homeostasis.
MeSH terms
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Animals
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Calcitriol
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Fibroblast Growth Factor-23
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Fibroblast Growth Factors
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Homeostasis
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Humans
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Hypophosphatemia / drug therapy
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Hypophosphatemia / etiology
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Kidney Failure, Chronic / complications*
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Kidney Failure, Chronic / drug therapy
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Metabolic Networks and Pathways
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Phosphates / physiology*
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Phosphates / therapeutic use
Substances
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Phosphates
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Fibroblast Growth Factors
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Fibroblast Growth Factor-23
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Calcitriol