Total oxidant/antioxidant Status in Jaundiced Newborns Before and After Phototherapy

J Pediatr (Rio J). Jul-Aug 2007;83(4):319-22. doi: 10.2223/JPED.1645. Epub 2007 Jul 11.

Abstract

Objective: To assess the effect of phototherapy on serum oxidant and antioxidant status in hyperbilirubinemic full-term newborns.

Method: Thirty-four full-term infants from 3 to 10 days of age exposed to phototherapy were studied. The serum antioxidant status was assessed by measuring the total antioxidant capacity (TAC) and individual antioxidant components: vitamin C, uric acid, albumin, thiol contents and total bilirubin. The oxidant status was assessed by determining the total oxidant status (TOS), oxidative stress index (OSI) and individual oxidant components: malondialdehyde (MDA), and lipid hydroperoxide levels.

Results: Vitamin C, uric acid, total bilirubin and MDA concentration were significantly lower, whereas serum TOS, lipid hydroperoxide and OSI levels were significantly higher after phototherapy (p < 0.05). There were significant positive correlations between serum total bilirubin and MDA (r = 0.434, p = 0.001).

Conclusions: Although the MDA level was reduced after phototherapy, phototherapy has a negative impact on numerous parts of the oxidant/antioxidant defense system in jaundiced full-term newborns, exposing them to potential oxidative stress.

Publication types

  • Validation Study

MeSH terms

  • Ascorbic Acid / blood
  • Biomarkers / blood
  • Female
  • Humans
  • Infant, Newborn
  • Jaundice, Neonatal / blood*
  • Jaundice, Neonatal / therapy
  • Lipid Peroxides / blood
  • Male
  • Malondialdehyde / blood
  • Oxidative Stress*
  • Phototherapy / adverse effects*
  • Uric Acid / blood

Substances

  • Biomarkers
  • Lipid Peroxides
  • Uric Acid
  • Malondialdehyde
  • Ascorbic Acid