The use of the antifungal agent miconazole as an inhibitor of Blastocystis hominis growth in Entamoeba histolytica/E. dispar cultures

Rev Inst Med Trop Sao Paulo. 2007 May-Jun;49(3):201-2. doi: 10.1590/s0036-46652007000300013.


In regions with high prevalence, Blastocystis hominis is frequently found in association with Entamoeba histolytica/E. dispar in xenic cultures. Its exacerbated growth is often superimposed on the growth of amebas, thus impeding the continuation of the amebas in the culture, within a few generations. The present study reports on the excellent efficacy (100%) of the antifungal agent miconazole in eliminating B. hominis from cultures of E. histolytica/E. dispar, thereby maintaining the integrity of the trophozoites of the amebas. Nystatin presented low efficacy (33.3%).

MeSH terms

  • Animals
  • Antifungal Agents / pharmacology*
  • Blastocystis hominis / drug effects*
  • Culture Media*
  • Entamoeba / growth & development*
  • Entamoeba histolytica / growth & development
  • Miconazole / pharmacology*
  • Microbial Sensitivity Tests


  • Antifungal Agents
  • Culture Media
  • Miconazole