Evaluation of the effectiveness of two infectious bronchitis virus vaccine programs for preventing disease caused by a California IBV field isolate

Avian Dis. 2007 Jun;51(2):584-9. doi: 10.1637/0005-2086(2007)51[584:EOTEOT]2.0.CO;2.


Infectious bronchitis virus CA99 serotype was isolated from several broiler flocks in Northern California. The virus caused late-onset respiratory disease and increased airsacculitis condemnation in affected flocks despite the use of an established infectious bronchitis virus vaccination program. An experimental study compared Holland/Arkansas and Massachusetts/Arkansas vaccination protocols to determine the efficacy of commercial infectious bronchitis virus vaccines in reducing respiratory disease and airsacculitis lesions found at processing that were associated with a CA99 field isolate. All vaccination groups were given Massachusetts/Connecticut strains of infectious bronchitis virus vaccines at age 1 day followed by vaccination with either Holland/ Arkansas or Massachusetts/Arkansas vaccine strains at 18 days of age. Birds were challenged at age 31 days with a CA99 field isolate. Gross pathology, histopathology, and virus isolation were evaluated. Chickens vaccinated with Holland/Arkansas had marginally better protection against CA99 challenge than chickens vaccinated with Massachusetts/Arkansas, although differences were not statistically significant.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Air Sacs / pathology
  • Animals
  • Antibodies, Viral / blood
  • California / epidemiology
  • Chickens / virology*
  • Coronavirus Infections / immunology
  • Coronavirus Infections / pathology
  • Coronavirus Infections / prevention & control
  • Coronavirus Infections / veterinary*
  • Infectious bronchitis virus / immunology*
  • Poultry Diseases / immunology*
  • Poultry Diseases / pathology
  • Poultry Diseases / prevention & control*
  • Poultry Diseases / virology
  • Time Factors
  • Trachea / pathology
  • Viral Vaccines / immunology*


  • Antibodies, Viral
  • Viral Vaccines