Effect of fluoxetine alone and in combination with sildenafil in patients with premature ejaculation

Urol Int. 2007;79(1):28-32. doi: 10.1159/000102909.


Introduction: The aim of this study was to compare the efficacy of fluoxetine alone and combined with sildenafil in patients complaining of premature ejaculation.

Patients and methods: Ninety-one married potent men, 21-43 years old, with premature ejaculation but without any obvious organic cause were enrolled. Pretreatment evaluation included history, physical examination, and self-administration of the International Index of Erectile Function questionnaire. The patients were randomly divided into two groups: group A patients (n = 48) received 20 mg fluoxetine daily for 4 weeks and then 20 mg as needed 2-3 h before sexual activity for 4 months, and group B patients (n = 43) received group A regimen plus 50 mg sildenafil as needed 1 h before sexual activity for 4 months.

Results: Ejaculatory latency time and intercourse satisfaction significantly improved in group B as compared with group A (p < 0.05).

Conclusion: Fluoxetine combined with sildenafil seems to provide significantly better ejaculatory latency time and intercourse satisfaction as compared with fluoxetine alone in patients with premature ejaculation.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Drug Therapy, Combination
  • Ejaculation*
  • Fluoxetine / therapeutic use*
  • Humans
  • Male
  • Phosphodiesterase Inhibitors / therapeutic use*
  • Piperazines / therapeutic use*
  • Prospective Studies
  • Purines / therapeutic use
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*
  • Sexual Dysfunction, Physiological / drug therapy*
  • Sildenafil Citrate
  • Single-Blind Method
  • Sulfones / therapeutic use*
  • Time Factors


  • Phosphodiesterase Inhibitors
  • Piperazines
  • Purines
  • Serotonin Uptake Inhibitors
  • Sulfones
  • Fluoxetine
  • Sildenafil Citrate