Interaction profiling of T-cell epitopes with MHC-class I molecules

Banaja Priyardarshini Dash; Sumanto Mukherjee; V L Suhas; Nagasuma Chandra

doi:10.2174/092986607780989994

Interaction profiling of T-cell epitopes with MHC-class I molecules

Protein Pept Lett. 2007;14(6):557-64. doi: 10.2174/092986607780989994.

Authors

Banaja Priyardarshini Dash¹, Sumanto Mukherjee, V L Suhas, Nagasuma Chandra

Affiliation

¹ Bioinformatics Centre and Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore, India.

PMID: 17627596
DOI: 10.2174/092986607780989994

Abstract

A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We report a structural bioinformatics study of peptide-HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Computational Biology / methods
Databases, Protein
Epitope Mapping / methods
Epitopes, T-Lymphocyte / genetics
Epitopes, T-Lymphocyte / immunology*
Epitopes, T-Lymphocyte / metabolism
Histocompatibility Antigens Class I / genetics
Histocompatibility Antigens Class I / immunology*
Histocompatibility Antigens Class I / metabolism
Peptides / chemistry
Peptides / immunology*
Peptides / metabolism
Protein Interaction Mapping

Substances

Epitopes, T-Lymphocyte
Histocompatibility Antigens Class I
Peptides