A profile of neuropsychiatric problems and their relationship to quality of life for Parkinson's disease patients without dementia

Parkinsonism Relat Disord. 2008;14(1):37-42. doi: 10.1016/j.parkreldis.2007.05.009. Epub 2007 Jul 12.


Neuropsychiatric problems are common in Parkinson's disease (PD) but there is little information regarding how they impact on quality of life. PD patients without dementia (49) were assessed for low mood/depression, fatigue, apathy, sleep problems and hallucinations. Measures of quality of life and motor function were also obtained. Over 77% of the patients reported symptoms consistent with one or more neuropsychiatric problems. Low mood/depression, anxiety and the presence of hallucinations predicted poorer quality of life after controlling for motor symptoms. Additional to the motor symptoms, we found that specific neuropsychiatric problems may impact on quality of life for PD patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dementia
  • Depression / etiology
  • Fatigue / etiology
  • Hallucinations / etiology
  • Humans
  • Neuropsychological Tests
  • Parkinson Disease / complications*
  • Parkinson Disease / psychology*
  • Quality of Life*
  • Sleep Wake Disorders / etiology
  • Tremor / etiology
  • Tremor / psychology