Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition

Lorenzo Camarda; Vita Di Stefano; Sergio Fatta Del Bosco; Domenico Schillaci

doi:10.1016/j.fitote.2007.02.020

Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition

Fitoterapia. 2007 Sep;78(6):426-9. doi: 10.1016/j.fitote.2007.02.020. Epub 2007 May 23.

Authors

Lorenzo Camarda¹, Vita Di Stefano, Sergio Fatta Del Bosco, Domenico Schillaci

Affiliation

¹ Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, via Archirafi 32, 90123, Palermo, Italy. camarnat@unipa.it

PMID: 17628348
DOI: 10.1016/j.fitote.2007.02.020

Abstract

The antiproliferative activity of fresh fruit juices extracted from Citrus sinensis (cv. Washington Navel and cv. Sanguinello), C. deliciosa cv. Avana, C. clementina cv. Nules, C. aurantium subsp. myrtifolia , was evaluated against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and MCF-7 (human breast adenocarcinoma) cell lines. All the juices tested showed antiproliferative activity. Moreover, the pattern of the main flavanone compounds in the juices has been determined by HPLC analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / administration & dosage
Antineoplastic Agents, Phytogenic / pharmacology*
Antineoplastic Agents, Phytogenic / therapeutic use
Cell Line, Tumor / drug effects
Cell Proliferation / drug effects*
Chromatography, High Pressure Liquid
Citrus*
Flavanones / administration & dosage
Flavanones / chemistry
Flavanones / pharmacology
Flavanones / therapeutic use
Fruit
HL-60 Cells / drug effects
Humans
K562 Cells / drug effects
Phytotherapy*

Substances

Antineoplastic Agents, Phytogenic
Flavanones
flavanone