Efficacy of local sclerosing agents on hemostasis of hepatic bleeding

Hepatogastroenterology. 2007 Jun;54(76):1212-5.


Background/aims: Hepatic bleeding following abdominal trauma is a serious problem. The implementation of various materials and techniques have been attempted to prevent bleeding but a standard method is indefinite.

Methodology: Hepatic resection model was performed on rats. The efficacy of hemostasis with Polidocanol and Tetradecyl Sulfate has been evaluated through the comparison of perioperative bleeding amount and preoperative and postoperative hematocrit levels in the 24th hour. Also, histopathologic changes on parenchyma have been compared at a microscopic level.

Results: Preoperative and postoperative hematocrit differences were 5.50 +/- 0.59 in Polidocanol group and 10 +/- 1.30 in Tetradecyl Sulfate group (MW: 2, p < 0.001). Perioperative bleeding amounts were: 1.50 +/- 0.20 mL in the Polidocanol group, 3.50 +/- 0.15 mL in the Tetradecyl Sulfate group and 7.50 +/- 0.41 mL in the Control Group. Upon comparison of perioperative bleeding amounts: the Control Group values were very high in comparison to the Polidocanol group (p < 0.001) and the Tetradecyl Sulfate group values were higher than those of the Polidocanol group (p < 0.05).

Conclusions: Local sclerosing agents, especially Polidocanol, appear to be an effective alternative method in hemostasis of hepatic bleeding.

MeSH terms

  • Animals
  • Female
  • Hemorrhage / drug therapy*
  • Hemostasis / drug effects*
  • Liver Diseases / drug therapy*
  • Polidocanol
  • Polyethylene Glycols / pharmacology
  • Polyethylene Glycols / therapeutic use*
  • Rats
  • Rats, Wistar
  • Sclerosing Solutions / pharmacology
  • Sclerosing Solutions / therapeutic use*
  • Sodium Tetradecyl Sulfate / therapeutic use*


  • Sclerosing Solutions
  • Polidocanol
  • Polyethylene Glycols
  • Sodium Tetradecyl Sulfate