RNA polymerase II: just stopping by

Matthew C Lorincz; Dirk Schübeler

doi:10.1016/j.cell.2007.06.040

RNA polymerase II: just stopping by

Cell. 2007 Jul 13;130(1):16-8. doi: 10.1016/j.cell.2007.06.040.

Authors

Matthew C Lorincz¹, Dirk Schübeler

Affiliation

¹ Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. mlorincz@interchange.ubc.ca

PMID: 17632051
DOI: 10.1016/j.cell.2007.06.040

Abstract

In this issue of Cell, Guenther et al. (2007) analyze the presence of chromatin marks and RNA polymerase at transcription start sites in the human genome. Their results reveal that many "inactive" genes harbor histone marks associated with active transcription at their 5' ends and that although these genes initiate transcription, they do not generate full-length transcripts.

Publication types

Comment

MeSH terms

Chromatin / metabolism
Gene Expression Regulation*
Genome, Human
Humans
RNA Polymerase II / genetics
RNA Polymerase II / metabolism*
Transcription, Genetic*

Substances

Chromatin
RNA Polymerase II