Granulocyte Colony-Stimulating Factor for the Induction of T-cell Tolerance

Transplantation. 2007 Jul 15;84(1 Suppl):S26-30. doi: 10.1097/01.tp.0000269611.66517.bf.

Abstract

In recent years, investigators have unraveled a previously unrecognized role for granulocyte colony-stimulating factor (G-CSF) in the regulation of T-cell and dendritic cell functions. The experimental evidence in favor of G-CSF-mediated immune regulation includes the ability to skew T-cell cytokine secretion to T-helper type 2 responses, and to promote regulatory T-cell and tolerogenic dendritic cell differentiation. Accordingly, beneficial effects of G-CSF have been detected in animal models of immune-mediated diseases, including posttransplantation graft-versus-host disease, experimental autoimmune encephalomyelitis, lupus nephritis, inflammatory bowel disease, and diabetes. The growing body of evidence supporting a novel role for G-CSF in the induction of T-cell tolerance is reviewed herein.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytokines / biosynthesis
  • Dendritic Cells / immunology
  • Granulocyte Colony-Stimulating Factor / immunology*
  • Granulocyte Colony-Stimulating Factor / pharmacology
  • Humans
  • Immune Tolerance / drug effects
  • Immune Tolerance / immunology*
  • Models, Immunological
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*

Substances

  • Cytokines
  • Granulocyte Colony-Stimulating Factor