Diversity in cell surface sialic acid presentations: implications for biology and disease

Lab Invest. 2007 Sep;87(9):851-7. doi: 10.1038/labinvest.3700656. Epub 2007 Jul 16.


Sialic acids (Sias) are typically found as terminal monosaccharides attached to cell surface glycoconjugates. They play many important roles in many physiological and pathological processes, including microbe binding that leads to infections, regulation of the immune response, the progression and spread of human malignancies and in certain aspects of human evolution. This review will provide some examples of these diverse roles of Sias and briefly address immunohistochemical approaches to their detection.

Publication types

  • Review

MeSH terms

  • Animals
  • Gangliosides
  • Humans
  • Immunohistochemistry
  • Lectins / immunology
  • Neoplasms / immunology
  • Organ Specificity / immunology
  • Organ Specificity / physiology*
  • Sialic Acid Binding Immunoglobulin-like Lectins
  • Sialic Acids / analysis
  • Sialic Acids / chemistry*
  • Sialic Acids / physiology*


  • Gangliosides
  • Lectins
  • Sialic Acid Binding Immunoglobulin-like Lectins
  • Sialic Acids