TRAF proteins in CD40 signaling

Adv Exp Med Biol. 2007;597:131-51. doi: 10.1007/978-0-387-70630-6_11.


The tumor necrosis factor receptor (TNFR) superfamily molecule CD40 is expressed by a wide variety of cell types following activation signals, and constitutively on B lymphocytes, macrophages, and dendritic cells. CD40 signals to cells stimulate kinase activation, gene expression, production of a antibody and a variety of cytokines, expression or upregulation of surface molecules, and protection or promotion of apoptosis. Initial steps in CD40-mediated signal cascades involve the interactions of CD40 with various members of the TNFR-associated factor (TRAF) family of cytoplasmic proteins. This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions.

Publication types

  • Review

MeSH terms

  • Animals
  • CD40 Antigens / physiology*
  • Humans
  • Signal Transduction / immunology*
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / physiology*


  • CD40 Antigens
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins