Complementary and alternative medicine (CAM) is a growing area of public interest. With increasing numbers of patients using these modalities, it is essential that Western medical practitioners become familiar with the available CAM literature to facilitate better patient care. While the volume of CAM research in gastrointestinal disorders has increased, there are still few modalities for which definitive conclusions can be made. This review will provide an overview of current knowledge of CAM therapies for functional gastrointestinal disorders, inflammatory bowel disease and liver disease. An understanding of this evolving literature is useful in discussing these therapies with patients who use, or are considering using, them. As we learn more about these CAM modalities, integration of those shown to be effective into our conventional practice and avoidance of those shown to be risky or of little use will be of benefit both to patients and practitioners.