[Effect of Fuzheng Peiben therapy on dendritic cell in patients with breast cancer]

Zhong Yao Cai. 2007 Mar;30(3):377-80.
[Article in Chinese]

Abstract

Objective: To investigate the repairing mechanism of Fuzheng Peiben Therapy on cellular immunofunction in patients with breast cancer on cellar and molecular level.

Methods: The tumor tissue and axillary lymph node samples were evaluated with the flow cytometry for CD83, CD80, CD86 before and after neoadujvant therapy.

Results: The levels of CD83, CD80, CD86 were singificantly decreased in group A (treated with surgery only), B (treated with neoadujvant chemotherapy plus surgery) and C (treated with neoadujvant chemotherapy plus surgery with shenqi Fuzheng Injection) compared with that in normal team (P < 0.05 or 0.01); The levels of CD83, CD80, CD86 were significantly decreased in group A, B and C compared between before and after neoadujvant chemotherapy (P < 0.05 or 0.01); They were not significantly decreased between group A and group C (P > 0.05).

Conclusion: The cellular immunity was inpaired considerably by neoadujvant chemotherapy. Neoadjuvant chemotherapy combined with Shenqi Fuzheng Injection can enhance the cellular immunity considerably.

MeSH terms

  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / immunology
  • Dendritic Cells / drug effects*
  • Dendritic Cells / immunology
  • Drugs, Chinese Herbal / chemistry*
  • Humans
  • Immunity, Cellular / drug effects*

Substances

  • Drugs, Chinese Herbal
  • shenqi fuzheng