Methods of evaluating the effect of pharmacological drugs on aging and life span in mice

Vladimir N Anisimov; Irina G Popovich; Mark A Zabezhinski

doi:10.1007/978-1-59745-361-5_17

Methods of evaluating the effect of pharmacological drugs on aging and life span in mice

Methods Mol Biol. 2007:371:227-36. doi: 10.1007/978-1-59745-361-5_17.

Authors

Vladimir N Anisimov¹, Irina G Popovich, Mark A Zabezhinski

Affiliation

¹ Department of Carcinogenis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.

PMID: 17634585
DOI: 10.1007/978-1-59745-361-5_17

Abstract

The methodology of testing anti-aging drugs in laboratory mice is presented. It includes the selection of mouse strain, sex, age at start of treatment, housing conditions, design of the long-term study, some noninvasive methods of assessment, pathology examination, and statistical treatment of the results.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging* / drug effects
Animals
Drug Evaluation, Preclinical*
Humans
Mice
Models, Biological*